Lizzy Caplan started out with a small role on the the coming-of-age period drama "Freaks and Geeks" (set in the early 1980s) as Sara, a high school student and the girlfriend of Nick Andopolis (played by Jason Segel, best known for his role on "How I Met Your Mother"). "Freaks and Geeks" was one of those shows that, unfortunately, received for more raves from the press than it did viewers, and so it was canceled after one season.
After more TV roles, Ms. Caplan broke through playing teenager Janis Ian (not to be confused with the real-life folk singer) in 2004's Mean Girls (2004) and as Marlena Diamond in the 2008 horror film Cloverfield, among other movies. This all led to her best-known role to date - as Virginia Johnson in "Masters of Sex," based on the real-life research of Johnson and William H. Masters into human sexual response and sexual dysfunction from the late 1950s to the 1970s.
The series ran on Showtime from 2013 to 2016.
Fun fact: Ms. Caplan's maternal uncle is writer and television pundit Howard Bragman.